MSc Project Biology - Molecular Cancer Research (m/f/d)
Goethe Universität Frankfurt am Main
The Institute of Experimental Cancer Research in Pediatrics of the Johann Wolfgang Goethe-University Frankfurt am Main conducts fundamental and translational research in pediatric cancer and the underlying signaling pathways with the aim of identifying novel targets for cancer therapy. The main research interest of the laboratory of Dr. Sjoerd van Wijk is to investigate how ubiquitination and autophagy control cell survival and cell death in healthy conditions and cancer. Our focus is on unravelling the biological functions and molecular mechanisms of how key enzymes in the ubiquitin pathway, like E3 ligases and deubiquitinating enzymes, are deregulated in pediatric cancers. In addition, we investigate the roles of autophagy in the regulation of cell death and are interested in understanding how death receptors control cell fate. For this, we apply highly inter-disciplinary approaches, including CRISPR/Cas9-mediated gene inactivation, advanced mass-spectrometry and high-content imaging using pediatric cancer cell lines, patient-derived material and preclinical mouse models. Applications are open for motivated, talented and curious MSc students (Molecular Medicine, Molecular Biology, Biotechnology or Biology). Potential candidates with a completed BSc degree in a relevant field and with skills in cell and molecular biology are very welcome to apply. We are looking for candidates who are highly self-motivated, creative and organized team players who will join our young, international and dynamic research team. We offer an excellent supervision by an experienced PhD student or post-doc and exciting research in well-equipped research laboratories. MSc projects (6-12 months) can start immediately or at any time point, upon mutual agreement.